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View-invariant human action recognition via robust locally adaptive multi-view learning

Jia-geng FENG,Jun XIAO

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 11,   Pages 917-920 doi: 10.1631/FITEE.1500080

Abstract: procedure, a robust locally adaptive multi-view learning algorithm based on learning multiple local L1

Keywords： View-invariant     Action recognition     Multi-view learning     L1-norm     Local learning    

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PD-1/PD-L1 blockade in cervical cancer: current studies and perspectives

Yumeng Wang, Guiling Li

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 438-450 doi: 10.1007/s11684-018-0674-4

Abstract: Checkpoint blockades targeting the PD-1/PD-L1 axis have achieved effective clinical responses with acceptableIn this review, we summarize recent advances in our understanding of the PD-1/PD-L1 signaling pathway, including the expression patterns of PD-1/PD-L1 and potential PD-1/PD-L1-related therapeutic strategies

Keywords： PD-1     PD-L1     immune checkpoint blockade antibody     immunotherapy     cervical cancer    

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Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Frontiers of Medicine   Pages 805-822 doi: 10.1007/s11684-023-1025-7

Abstract: To date, immune checkpoint inhibitors (ICIs) of CTLA-4 and PD-1/PD-L1 represent the main class of immunotherapyBlockade of CTLA-4 and PD-1/PD-L1 has shown remarkable efficacy in several specific types of cancers,generalized mechanism of targeting cancer metabolism at three crucial immune checkpoints (CTLA-4, PD-1,and PD-L1) to influence ICB therapy and propose potential combined immunotherapeutic strategies co-targeting

Keywords： CTLA-4     PD-1     PD-L1     immune checkpoint blockade (ICB)     metabolic reprogramming     combined tumor therapeutic    

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Activation of phagocytosis by immune checkpoint blockade

Chia-Wei Li, Yun-Ju Lai, Jennifer L. Hsu, Mien-Chie Hung

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 473-480 doi: 10.1007/s11684-018-0657-5

Abstract: On the basis of a recently discovered programmed death protein 1 (PD-1) in TAMs, we discuss the potential

Keywords： CD47     PD-1     PD-L1     immunotherapy     TAM     phagocytosis     macrophage    

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Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells

LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 269-273 doi: 10.1007/s11684-007-0051-1

Abstract: the influence and the related mechanism of the gene on glucose uptake and insulin resistance in 3T3-L1Radioimmunoassay was used to determine glucose uptake in 3T3-L1 cells with different gene expressionRT-PCR analysis were used to determine the mRNA levels of several glucose transport proteins in 3T3-L1The glucose uptake decreased with the increase in gene expression in 3T3-L1 cells, which was independentdecreased and the other two signal proteins, GSK-3 and p38MAPK, increased with overexpression in 3T3-L1

Keywords： 3T3-L1     influence     resistance     receptor substrate-1     transport    

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Hao Wang, Zhi-yuan Wang, Ben-dong Wang, Zhong-he Jin, John L. Crassidis,roger@zju.edu.cn

Frontiers of Information Technology & Electronic Engineering 2021, Volume 22, Issue 2,   Pages 141-286 doi: 10.1631/FITEE.1900358

Abstract: s are widely used in attitude-determination and control systems of satellites. The main deficiency of static s is the requirement of a small field of view (FOV). A typical FOV for a static is about 20° to 30°, which may not be sufficient for low-Earth-orbiting s. A novel compact with an FOV of nearly 180° is developed here. The Earth sensor comprises a panoramic annular lens (PAL) and an off-the-shelf camera with an uncooled complementary-metal-oxide-semiconductor (CMOS) infrared sensor. PAL is used to augment FOV so as to obtain a complete infrared image of the Earth from low-Earth-orbit. An algorithm is developed to compensate for the distortion caused by PAL and to calculate the vector of the Earth. The new is compact with low power consumption and high precision. Simulated images and on-orbit infrared images obtained via the ZDPS-2 are used to assess the performance of the new . Experiments show that the accuracy of the Earth sensor is about 0.032°.

Keywords： Infrared Earth sensor     Micro-satellite     Attitude determination system    

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A block zero-padding method based on DCFT for L1 parameter estimations in weak signal and high dynamic

Chao WU,Lu-ping XU,Hua ZHANG,Wen-bo ZHAO

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 9,   Pages 796-804 doi: 10.1631/FITEE.1500058

Abstract: Weak L1 signal acquisition in a high dynamic environment primarily faces a challenge: the integration

Keywords： Threshold detection     Discrete chirp-Fourier transform     Block zero-padding     High dynamic     Weak L1 signal    

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Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 229-235 doi: 10.1007/s11684-017-0581-0

Abstract: refractory Hodgkin lymphoma, and urothelial carcinoma, all of which carry positive programmed death-1/programmed death-ligand 1 biomarkers.

Keywords： molecular classification     precision medicine     pembrolizumab     PD-1/PD-L1     MSI-H    

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of the agglomeration of crystals in the reactive crystallization of 5-(difluoromethoxy)-2-mercapto-1

Yongli WANG, Shuyuan MA, Xiaodong Lü, Chuang XIE

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 4,   Pages 423-431 doi: 10.1007/s11705-012-1211-7

Abstract: 5-(Difluoromethoxy)-2-mercapto-1 -benzimidazole (DMB) was precipitated by adding acetic acid to the DMB

Keywords： 5-(difluoromethoxy)-2-mercapto-1H-benzimidazole (DMB)     reactive crystallization     agglomeration    

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Parameter value selection strategy for complete coverage path planning based on the Lü system to perform Research Article

Caihong LI, Cong LIU, Yong SONG, Zhenying LIANG

Frontiers of Information Technology & Electronic Engineering 2023, Volume 24, Issue 2,   Pages 231-244 doi: 10.1631/FITEE.2200211

Abstract: We propose a novel for the ; to construct a chaotic robot to accomplish the task. The algorithm can meet the requirements of high randomness and coverage rate to perform specific types of missions. First, we roughly determine the value range of the parameter of the ; to meet the requirement of being a dissipative . Second, we calculate the s to narrow the value range further. Next, we draw the phase planes of the to approximately judge the topological distribution characteristics of its trajectories. Furthermore, we calculate the of the variable for those good ones to judge its random characteristics. Finally, we construct a chaotic robot using variables with the determined parameter values and simulate and test the coverage rate to study the relationship between the coverage rate and the random characteristics of the variables. The above selection strategy gradually narrows the value range of the parameter according to the randomness requirement of the coverage trajectory. Using the proposed strategy, proper variables can be chosen with a larger to construct a chaotic robot with a higher coverage rate. Another chaotic , the Lorenz , is used to verify the feasibility and effectiveness of the designed strategy. The proposed strategy for enhancing the coverage rate of the mobile robot can improve the efficiency of accomplishing CCPP tasks under specific types of missions.

Keywords： Chaotic mobile robot     Lü     system     Complete coverage path planning (CCPP)     Parameter value selection strategy    

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Resolving the Adhesive Behavior of 1D Materials: A Review of Experimental Approaches Review

James L. Mead, Shiliang Wang, Sören Zimmermann, Sergej Fatikow, Han Huang

Engineering 2023, Volume 24, Issue 5,   Pages 39-72 doi: 10.1016/j.eng.2023.02.012

Abstract:

The adhesive behavior of one-dimensional (1D) materials, such as nanotubes and nanowires, plays adecisive role in the effective fabrication, functionality, and reliability of novel devices that integrate 1Dcomponents, as well as in biomimetic adhesives based on 1D arrays.recent experimental techniques that aim to characterize the adhesion behavior of interfaces formed by 1DThe conformation of 1D material to surfaces and the associated occurrence of multi-asperity contact are

Keywords： Interface adhesion     1D materials     Nanowire     Carbon nanotube     Nanomanipulation     Surface forces     Mechanical    

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Application of StrucGP in medical immunology: site-specific -glycoproteomic analysis of macrophages

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 304-316 doi: 10.1007/s11684-022-0964-8

Abstract: In this work, we used THP-1-derived macrophages as examples to show the vast potential of a N-bisected GlcNAc, core fucosylated, and sialylated glycans (e.g., HexNAc4Hex5Fuc1Neu5Ac1, N4H5F1S1) were increased in M1 andIn addition, a high level of glycosylated PD-L1 was observed in M1 macrophages, and the LacNAc moietywas detected at Asn-192 and Asn-200 of PD-L1, and Asn-200 contained Lewis epitopes.

Keywords： macrophage     glycoproteome     glycopeptides     N-glycan structures     PD-L1    

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High-Affinity Decoy PD-1 Mutant Screened from an Epitope-Specific Cell Library Article

Hao Liu, Chunxia Qiao, Naijing Hu, Zhihong Wang, Jing Wang, Jiannan Feng, Beifen Shen, Yuanfang Ma, Longlong Luo

Engineering 2021, Volume 7, Issue 11,   Pages 1557-1565 doi: 10.1016/j.eng.2020.11.011

Abstract: -1 (PD-L1) monoclonal antibodies has become routine in the treatment of many kinds of human cancers,Wild-type (WT) PD-1 ectodomain has been shown to have difficulty blocking PD-1/PD-L1 mixture formationbinds to PD-L1 or PD-L2.Based on the theoretical binding analysis of PD-1 and its ligands (i.e., PD-L1 and PD-L2) or antibodyPD-L1-related cancers.

Keywords： Decoy PD-1     PD-L1     Mammalian cell library     Epitope-oriented    

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Smartphone-Imaged HIV-1 Reverse-Transcription Loop-Mediated Isothermal Amplification (RT-LAMP) on a Chip Article

Gregory L. Damhorst,Carlos Duarte-Guevara,Weili Chen,Tanmay Ghonge,Brian T. Cunningham,Rashid Bashir

Engineering 2015, Volume 1, Issue 3,   Pages 324-335 doi: 10.15302/J-ENG-2015072

Abstract: viruses in a ~ 60 nL RT-LAMP droplet, corresponding to a whole blood concentration of 670 viruses per μL

Keywords： human immunodeficiency virus (HIV)     viral load     loop-mediated isothermal amplification     smartphone     point-of-care    

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Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy

Min Zhang, Jingwen Yang, Wenjing Hua, Zhong Li, Zenghui Xu, Qijun Qian

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 32-44 doi: 10.1007/s11684-018-0678-0

Abstract:

Immunotherapy has become the fourth cancer therapy after surgery, chemotherapy, and radiotherapy. In particular, immune checkpoint inhibitors are proved to be unprecedentedly in increasing the overall survival rates of patients with refractory cancers, such as advanced melanoma, non-small cell lung cancer, and renal cell carcinoma. However, inhibitor therapies are only effective in a small proportion of patients with problems, such as side effects and high costs. Therefore, doctors urgently need reliable predictive biomarkers for checkpoint inhibitor therapies to choose the optimal therapies. Here, we review the biomarkers that can serve as potential predictors of the outcomes of immune checkpoint inhibitor treatment, including tumor-specific profiles and tumor microenvironment evaluation and other factors.

Keywords： immune checkpoint     companion diagnosis     PD-L1     tumor mutation burden     immune score    

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Title Author Date Type Operation

View-invariant human action recognition via robust locally adaptive multi-view learning

Jia-geng FENG,Jun XIAO

Journal Article

PD-1/PD-L1 blockade in cervical cancer: current studies and perspectives

Yumeng Wang, Guiling Li

Journal Article

Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Journal Article

Activation of phagocytosis by immune checkpoint blockade

Chia-Wei Li, Yun-Ju Lai, Jennifer L. Hsu, Mien-Chie Hung

Journal Article

Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells

LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan

Journal Article

N

Hao Wang, Zhi-yuan Wang, Ben-dong Wang, Zhong-he Jin, John L. Crassidis,roger@zju.edu.cn

Journal Article

A block zero-padding method based on DCFT for L1 parameter estimations in weak signal and high dynamic

Chao WU,Lu-ping XU,Hua ZHANG,Wen-bo ZHAO

Journal Article

Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Journal Article

of the agglomeration of crystals in the reactive crystallization of 5-(difluoromethoxy)-2-mercapto-1

Yongli WANG, Shuyuan MA, Xiaodong Lü, Chuang XIE

Journal Article

Parameter value selection strategy for complete coverage path planning based on the Lü system to perform

Caihong LI, Cong LIU, Yong SONG, Zhenying LIANG

Journal Article

Resolving the Adhesive Behavior of 1D Materials: A Review of Experimental Approaches

James L. Mead, Shiliang Wang, Sören Zimmermann, Sergej Fatikow, Han Huang

Journal Article

Application of StrucGP in medical immunology: site-specific -glycoproteomic analysis of macrophages

Journal Article

High-Affinity Decoy PD-1 Mutant Screened from an Epitope-Specific Cell Library

Hao Liu, Chunxia Qiao, Naijing Hu, Zhihong Wang, Jing Wang, Jiannan Feng, Beifen Shen, Yuanfang Ma, Longlong Luo

Journal Article

Smartphone-Imaged HIV-1 Reverse-Transcription Loop-Mediated Isothermal Amplification (RT-LAMP) on a Chip

Gregory L. Damhorst,Carlos Duarte-Guevara,Weili Chen,Tanmay Ghonge,Brian T. Cunningham,Rashid Bashir

Journal Article

Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy

Min Zhang, Jingwen Yang, Wenjing Hua, Zhong Li, Zenghui Xu, Qijun Qian

Journal Article